Urolithin A Powder

Description

Urolithin A Powder
CAS Number	1143-70-0
Molar Mass	228.20 g/mol
Chemical Formula	C13H8O4
IUPAC Name	3,8-dihydroxy-6H-benzo[c]chromen-6-one

Introduction

Urolithin A Powder is a gut microbiota-derived polyphenol metabolite, classified as a postbiotic, supplied strictly for laboratory and in vitro research use. It is studied by researchers investigating mitochondrial quality control, skeletal muscle function, and inflammatory signaling pathways. Urolithin A is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.

Key Characteristics

Urolithin A Powder is manufactured to a high standard of chemical purity to support reproducible research outcomes. Each batch is formulated with attention to structural precision and lot-to-lot consistency, allowing researchers to rely on stable results across independent experiments.

Research Applications

Urolithin A is used in cell biology, muscle physiology, and immunology research to investigate mitophagy, the selective clearance of dysfunctional mitochondria, along with downstream effects on skeletal muscle performance and inflammatory receptor signaling. It serves as a mechanistic tool for probing how gut-derived polyphenol metabolites influence mitochondrial and cellular health in model systems.

Research Benefits

Urolithin A and Mitophagy

Research indicates that Urolithin A induces mitophagy both in vitro and following oral consumption in vivo, preventing the age-related accumulation of dysfunctional mitochondria. Studies have investigated this mechanism in Caenorhabditis elegans, where Urolithin A extended lifespan and preserved mobility and pharyngeal pumping activity while maintaining mitochondrial respiratory capacity, effects that translated into improved exercise capacity in rodent models of age-related muscle decline.

Urolithin A and Muscle Strength

Studies propose that Urolithin A supplementation supports skeletal muscle performance through its mitophagy-activating mechanism. Researchers use this model to explore how mitochondrial recycling relates to physical function, with a randomized, placebo-controlled trial finding that research participants showed improvements in muscle strength and aerobic endurance alongside reduced plasma acylcarnitines and C-reactive protein, markers associated with mitochondrial efficiency and inflammation.

Urolithin A and Inflammatory Signaling

Research suggests that Urolithin A acts as a direct ligand and antagonist of the aryl hydrocarbon receptor, a mechanism identified using cell-based reporter systems and competitive ligand binding assays. Studies have investigated this pathway in cultured intestinal epithelial cells, finding that aryl hydrocarbon receptor activity was required for Urolithin A’s attenuation of cytokine-induced interleukin-6 and prostaglandin-endoperoxide synthase 2 expression.

Summary

Urolithin A Powder is a gut microbiota-derived polyphenol metabolite supplied exclusively for laboratory research. It supports investigation into three distinct areas: mitophagy and mitochondrial quality control, skeletal muscle strength, and aryl hydrocarbon receptor-mediated inflammatory signaling. As with all research compounds in this catalog, Urolithin A is intended strictly for research use and not for human or veterinary application.

Disclaimer

This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.

Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).

Our informational content is meticulously designed for research-oriented insights and is not a substitute for individual analysis and verification from credible sources before any purchasing decisions are made.

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IMPORTANT NOTICE: All products showcased on our platform are EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH APPLICATIONS. They are expressly not intended for veterinary or human utilization.

References

1. Ryu D, Mouchiroud L, Andreux PA, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. PMID: 27400265. Read More
2. Singh A, D’Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022 May 17;3(5):100633. doi: 10.1016/j.xcrm.2022.100633. PMID: 35584623. Read More
3. Muku GE, Murray IA, Espín JC, Perdew GH. Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist. Metabolites. 2018 Nov 29;8(4):86. doi: 10.3390/metabo8040086. PMID: 30501068. Read More