BPAP

Description

BPAP
CAS Number	260550-89-8
Molar Mass	245.36 g/mol
Chemical Formula	C16H23NO
IUPAC Name	(R)-1-(1-Benzofuran-2-yl)-N-propylpentan-2-amine

Introduction

BPAP is a benzofuran derivative and small molecule nootropic compound supplied strictly for laboratory and in vitro research use. It is studied by researchers investigating monoaminergic signaling, neuronal impulse propagation, and neuroprotective cell mechanisms. BPAP is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.

Key Characteristics

BPAP is manufactured to a high standard of chemical purity to support reproducible research outcomes. Each batch is formulated with attention to structural precision and lot-to-lot consistency, allowing researchers to rely on stable results across independent experiments.

Research Applications

BPAP is used in neuropharmacology and cell biology research to investigate monoamine neurotransmitter dynamics, receptor-mediated signaling pathways, and neuronal cell survival mechanisms. It serves as a mechanistic tool for probing impulse-dependent transmitter release and downstream intracellular signaling cascades in model systems.

Research Benefits

BPAP and Catecholamine Release Modulation

Research suggests BPAP acts on trace amine-associated receptors to selectively enhance the impulse-propagation-mediated release of noradrenaline, dopamine, and serotonin from neuronal tissue, rather than causing a bulk, non-selective release of stored transmitter. Studies have investigated this bell-shaped, concentration-dependent effect in isolated brain tissue, offering researchers a tool to explore how trace amine receptor activity shapes monoaminergic output.

BPAP and Mitochondrial Neuroprotection

Studies propose that BPAP stabilizes mitochondrial membrane potential and upregulates the anti-apoptotic protein Bcl-2, which may contribute to protecting dopaminergic cells from apoptosis triggered by neurotoxic compounds. Researchers use this model to investigate stereochemistry-dependent neuroprotective mechanisms relevant to Parkinson’s disease cell biology research.

BPAP and Drug-Seeking Behavior Modulation

Research indicates that repeated and acute administration of BPAP may attenuate the reinstatement of methamphetamine-seeking behavior in animal models, an effect linked to downstream dopamine D1-like receptor signaling. This offers researchers a framework for investigating the neurochemical basis of relapse-related behavior in addiction studies.

Summary

BPAP is a benzofuran-derived small molecule nootropic supplied exclusively for laboratory research. It supports investigation into three distinct areas: monoaminergic release modulation, mitochondrial neuroprotection, and drug-seeking behavior in preclinical models. As with all research compounds in this catalog, BPAP is intended strictly for research use and not for human or veterinary application.

Disclaimer

This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.

Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).

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References

1. Knoll J, Miklya I, Knoll B. Stimulation of the catecholaminergic and serotoninergic neurons in the rat brain by R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, (-)-BPAP. Life Sci. 2002 Sep 20;71(18):2137-44. doi: 10.1016/s0024-3205(02)01969-0. PMID: 12204771. Read More
2. Maruyama W, Yi H, Takahashi T, Shimazu S, Ohde H, Yoneda F, Iwasa K, Naoi M. Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells. Life Sci. 2004 May 21;75(1):107-17. doi: 10.1016/j.lfs.2003.12.001. PMID: 15102525. Read More
3. Hiranita T, Yamamoto T, Nawata Y. A tryptamine-derived catecholaminergic enhancer, (-)-1-(benzofuran-2-yl)-2-propylaminopentane [(-)-BPAP], attenuates reinstatement of methamphetamine-seeking behavior in rats. Neuroscience. 2010 Jan 20;165(2):300-12. doi: 10.1016/j.neuroscience.2009.10.055. PMID: 19883738. Read More