SAM-e Powder

Description

SAM-e Powder
CAS Number	97540-22-2 Note: CAS 97540-22-2 applies to the disulfate tosylate salt form. MW and formula may vary by hydration state — verify against batch COA before quantitative assay use.
Molar Mass	766.80 g/mol
Chemical Formula	C22H34N6O16S4
IUPAC Name	(3S)-5′-[(3-Amino-3-carboxypropyl)methylsulfonio]-5′-deoxyadenosine disulfate tosylate

Introduction

SAM-e Powder is the disulfate tosylate salt form of S-adenosylmethionine, a naturally occurring coenzyme and methyl donor, supplied strictly for laboratory research use. It is studied by researchers investigating transmethylation reactions, mood-related neurotransmitter pathways, and hepatic and joint physiology. SAM-e is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.

Key Characteristics

SAM-e Powder is manufactured to a high standard of chemical purity to support reproducible research outcomes. The disulfate tosylate salt form offers greater thermal stability than the free base, which degrades rapidly under ambient conditions, allowing researchers to rely on stable results across independent experiments.

Research Applications

SAM-e is used in psychiatric, hepatology, and musculoskeletal research to investigate its role as the primary methyl donor in transmethylation reactions supporting neurotransmitter, protein, and lipid synthesis. It serves as a mechanistic tool for probing how methyl donor availability relates to mood regulation, hepatic cell function, and joint physiology in research participants and model systems.

Research Benefits

SAM-e and Mood-Related Outcomes

Research indicates that oral SAM-e, added alongside an existing serotonin reuptake inhibitor regimen, was associated with higher response and remission rates on a standardized mood rating scale compared to placebo. Studies have investigated this adjunctive approach in a double-blind, randomized trial among research participants who had not responded to their existing regimen, finding a favorable safety and tolerability profile over the six-week study period.

SAM-e and Hepatic Cell Function

Studies propose that S-adenosylmethionine supports liver cell function through its role as a methyl donor. Researchers use this model to explore how long-term oral administration relates to survival and time to liver transplantation, with a randomized, placebo-controlled, multicenter trial finding a significant survival benefit among research participants with less advanced liver disease at baseline.

SAM-e and Joint Function

Research suggests that SAM-e supports functional health measures and pain scores in a manner comparable to a cyclooxygenase-2 inhibitor, though with a slower onset of action. Studies have investigated this comparison in a double-blind, cross-over trial measuring pain, functional health, mood status, and isometric joint function tests over sixteen weeks in research participants.

Summary

SAM-e Powder is a coenzyme and methyl donor supplied exclusively for laboratory research. It supports investigation into three distinct areas: mood-related neurotransmitter pathways, hepatic cell function, and joint physiology. As with all research compounds in this catalog, SAM-e is intended strictly for research use and not for human or veterinary application.

Disclaimer

This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.

Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).

Our informational content is meticulously designed for research-oriented insights and is not a substitute for individual analysis and verification from credible sources before any purchasing decisions are made.

Upon finalizing your order and payment, you explicitly acknowledge and agree to adhere to our Terms and Conditions. Customer contentment stands as our paramount concern. If you are dissatisfied with the product received, kindly contact us at 419-707-5450 or email our support team at support@bc9.co. 

IMPORTANT NOTICE: All products showcased on our platform are EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH APPLICATIONS. They are expressly not intended for veterinary or human utilization.

References

1. Papakostas GI, Mischoulon D, Shyu I, Alpert JE, Fava M. S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial. Am J Psychiatry. 2010 Aug;167(8):942-8. doi: 10.1176/appi.ajp.2009.09081198. PMID: 20595412. Read More
2. Mato JM, Cámara J, Fernández de Paz J, et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol. 1999 Jun;30(6):1081-9. doi: 10.1016/s0168-8278(99)80263-3. PMID: 10406187. Read More
3. Najm WI, Reinsch S, Hoehler F, Tobis JS, Harvey PW. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. BMC Musculoskelet Disord. 2004 Feb 26;5:6. doi: 10.1186/1471-2474-5-6. PMID: 15102339. Read More