4-DMA-7,8-DHF (Free Base)

Description

4-DMA-7,8-DHF (Free Base)
CAS Number	1205548-04-4
Molar Mass	297.31 g/mol
Chemical Formula	C17H15NO4
IUPAC Name	2-[4-(dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one

Introduction

4-DMA-7,8-DHF (Free Base) is a synthetic flavonoid derivative and small molecule nootropic compound supplied strictly for laboratory and in vitro research use. It is studied by researchers investigating TrkB receptor signaling, neurotrophic factor pathways, and neuronal survival mechanisms. 4-DMA-7,8-DHF is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.

Key Characteristics

4-DMA-7,8-DHF (Free Base) is manufactured to a high standard of chemical purity to support reproducible research outcomes. Each batch is formulated with attention to structural precision and lot-to-lot consistency, allowing researchers to rely on stable results across independent experiments.

Research Applications

4-DMA-7,8-DHF is used in neuropharmacology and cell biology research to investigate TrkB receptor activation, downstream Akt and MAPK signaling, and their role in neuronal growth and survival. It serves as a mechanistic tool for probing how small-molecule BDNF mimetics influence neurogenesis, mood-related behavior, and motor neuron function in model systems.

Research Benefits

4-DMA-7,8-DHF and Neurotrophic Signaling

Research indicates that 4-DMA-7,8-DHF binds and activates the TrkB receptor, triggering the same downstream Akt and MAPK signaling cascades engaged by brain-derived neurotrophic factor. Studies have investigated this mechanism in animal models, where chronic oral administration promoted hippocampal neurogenesis and reduced markers of neuronal apoptosis compared to vehicle.

4-DMA-7,8-DHF and Motor Neuron Function

Studies propose that TrkB receptor activation by 4-DMA-7,8-DHF helps preserve striatal DARPP32 levels and supports neuronal survival in a transgenic mouse model of neurodegeneration. Researchers use this model to explore how restoring BDNF-TrkB signaling relates to improved motor coordination and extended survival in animals carrying a neurodegenerative disease-associated mutation.

4-DMA-7,8-DHF and Mood-Related Behavior

Research suggests that 4-DMA-7,8-DHF and its O-methylated metabolites both activate the TrkB receptor in brain tissue after oral administration, with COMT-mediated methylation contributing to sustained receptor activation. Studies have investigated this metabolic pathway alongside behavioral assays, in which reduced immobility in forced swim and tail suspension tests was observed following administration in animal models.

Summary

4-DMA-7,8-DHF (Free Base) is a synthetic flavonoid derivative supplied exclusively for laboratory research. It supports investigation into three distinct areas: TrkB-mediated neurotrophic signaling, motor neuron function in models of neurodegeneration, and mood-related behavioral pathways. As with all research compounds in this catalog, 4-DMA-7,8-DHF is intended strictly for research use and not for human or veterinary application.

Disclaimer

This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.

Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).

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References

1. Liu X, Chan CB, Jang SW, et al. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem. 2010 Nov 12;53(23):8274-86. doi: 10.1021/jm101206p. PMID: 21073191. Read More
2. Jiang M, Peng Q, Liu X, et al. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington’s disease. Hum Mol Genet. 2013 Feb 27;22(12):2462-70. doi: 10.1093/hmg/ddt098. PMID: 23446639. Read More
3. Liu X, Qi Q, Xiao G, Li J, Luo HR, Ye K. O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. Pharmacology. 2013 Feb 21;91(3-4):185-200. doi: 10.1159/000346920. PMID: 23445871. Read More