C60 Fullerene

Description

C60 Fullerene
CAS Number	99685-96-8
Molar Mass	720.66 g/mol
Chemical Formula	C60
IUPAC Name	(C60-Ih)[5,6]fullerene

Introduction

C60 Fullerene is a spherical carbon allotrope and nanomaterial composed of 60 carbon atoms arranged in a truncated icosahedral cage structure, supplied strictly for laboratory research use. It is studied by researchers investigating free radical chemistry, oxidative stress attenuation, and cellular and organismal aging processes. C60 Fullerene is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.

Key Characteristics

C60 Fullerene is manufactured to a high standard of chemical purity to support reproducible research outcomes. Each batch is formulated with attention to structural precision and lot-to-lot consistency, allowing researchers to rely on stable results across independent experiments.

Research Applications

C60 Fullerene is used in chemistry, toxicology, and aging research to investigate its capacity to react with and stabilize free radicals through its extended carbon cage surface. It serves as a mechanistic tool for probing how this radical-scavenging property relates to oxidative stress attenuation, DNA damage protection, and lifespan in model systems.

Research Benefits

C60 Fullerene and Free Radical Reactivity

Research indicates that C60 reacts readily with photochemically generated carbon-based radicals, forming stable radical adducts in which the unpaired electron becomes highly localized on the fullerene cage surface. Studies have investigated this reactivity using electron spin resonance spectroscopy and mass spectrometry, establishing the chemical basis for C60’s capacity to react with multiple radical species and provides a foundation for its investigation as a radical-scavenging agent.

C60 Fullerene and Oxidative Stress in Aging Models

Studies propose that repeated oral administration of C60 dissolved in olive oil attenuates age-associated increases in oxidative stress. Researchers use this model to explore how this mechanism relates to organismal aging, with a study in rats finding that this administration regimen did not produce chronic toxicity and was associated with a substantially extended lifespan compared to controls receiving olive oil alone.

C60 Fullerene and DNA Damage Protection

Research suggests that C60 nanoparticles reduce DNA fragmentation and chromosomal aberrations induced by a genotoxic chemotherapeutic agent in rat liver and heart tissue. Studies have investigated this protective effect using molecular DNA fragmentation assays and bone marrow cytogenetic analysis, finding that oral C60 administration decreased the frequency of chromosomal ring formation, deletions, and other aberrations compared to chemotherapeutic exposure alone.

Summary

C60 Fullerene is a spherical carbon allotrope supplied exclusively for laboratory research. It supports investigation into three distinct areas: free radical reactivity, oxidative stress attenuation in aging models, and DNA damage protection. As with all research compounds in this catalog, C60 Fullerene is intended strictly for research use and not for human or veterinary application.

Disclaimer

This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.

Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).

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IMPORTANT NOTICE: All products showcased on our platform are EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH APPLICATIONS. They are expressly not intended for veterinary or human utilization.

References

1. Krusic PJ, Wasserman E, Keizer PN, Morton JR, Preston KF. Radical reactions of C60. Science. 1991 Nov 22;254(5035):1183-5. doi: 10.1126/science.254.5035.1183. PMID: 17776407. Read More
2. Baati T, Bourasset F, Gharbi N, Njim L, Abderrabba M, Kerkeni A, Szwarc H, Moussa F. The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene. Biomaterials. 2012 Jul;33(19):4936-46. doi: 10.1016/j.biomaterials.2012.03.036. PMID: 22498298. Read More
3. Aly FM, Othman A, Haridy MAM. Protective Effects of Fullerene C60 Nanoparticles and Virgin Olive Oil against Genotoxicity Induced by Cyclophosphamide in Rats. Oxid Med Cell Longev. 2018 Jul 15;2018:1261356. doi: 10.1155/2018/1261356. PMID: 30116471. Read More