Description
| Compound 7P | |
| CAS Number | 1890208-58-8 |
| Molar Mass | 441.50 g/mol |
| Chemical Formula | C22H23N3O5S |
| IUPAC Name | 2-((N-(2-methoxyphenyl)-4-methylphenyl)sulfonamido)-N-(4-methoxypyridin-3-yl)acetamide |
Introduction
Compound 7P is a synthetic sulfonamide small molecule and nootropic research compound supplied strictly for laboratory and in vitro research use. It is studied by researchers investigating neurite outgrowth signaling and axon regeneration pathways. Compound 7P is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.
Key Characteristics
Compound 7P is manufactured to a high standard of chemical purity to support reproducible research outcomes. Each batch is formulated with attention to structural precision and lot-to-lot consistency, allowing researchers to rely on stable results across independent experiments.
Research Applications
Compound 7P is used in neuroscience and drug discovery research to investigate pharmacological approaches to axon growth in central nervous system neurons. It was identified through phenotypic cell-based screening of chemical libraries designed to find molecules that stimulate axon growth signaling pathways, and it serves as a tool for probing the mechanisms behind age-dependent decline in intrinsic axon growth potential.
Research Benefits
Compound 7P and Neurite Outgrowth
Research indicates that Compound 7P promotes neurite outgrowth in cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. Studies have investigated this effect through structure-activity-guided optimization, identifying Compound 7P as the lead molecule from a phenotypic screen designed to find inducers of axon growth.
Compound 7P and Axon Regeneration
Studies propose that Compound 7P induces the growth of GAP-43-positive axons in an animal model of optic nerve injury, indicating that its in vitro neurite outgrowth activity translates into axon regeneration in vivo. Researchers use this model to explore how pharmacological stimulation of axon growth signaling might apply to central nervous system injury research.
Summary
Compound 7P is a synthetic sulfonamide small molecule supplied exclusively for laboratory research. It supports investigation into two distinct areas: neurite outgrowth in primary neuron cultures and axon regeneration in a preclinical model of optic nerve injury. As with all research compounds in this catalog, Compound 7P is intended strictly for research use and not for human or veterinary application.
Disclaimer
This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.
Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).
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References
- Ku JM, Park K, Lee JH, et al. Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration. J Med Chem. 2016 Apr 22;59(10):4676-87. doi: 10.1021/acs.jmedchem.6b00015. PMID: 27007292. Read More
Koch JC, Tönges L, Barski E, Michel U, Bähr M, Lingor P. ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS. Cell Death & Disease. 2014;5:e1225. PMID: 24832598
https://pubmed.ncbi.nlm.nih.gov/24832598/
Yin Y, Henzl MT, Lorber B, et al. Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nature Neuroscience. 2006;9(6):843–852. PMID: 16699509
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