Idebenone Powder

Description

Idebenone Powder
CAS Number	58186-27-9
Molar Mass	338.44 g/mol
Chemical Formula	C19H30O5
IUPAC Name	2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Introduction

Idebenone Powder is a synthetic coenzyme Q10 analog and small molecule nootropic compound supplied strictly for laboratory and in vitro research use. It is studied by researchers investigating mitochondrial electron transport, antioxidant defense mechanisms, and neuroprotective signaling pathways. Idebenone is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.

Key Characteristics

Idebenone Powder is manufactured to a high standard of chemical purity to support reproducible research outcomes. Each batch is formulated with attention to structural precision and lot-to-lot consistency, allowing researchers to rely on stable results across independent experiments.

Research Applications

Idebenone is used in mitochondrial biology and neuropharmacology research to investigate electron transport chain function, cellular ATP production under conditions of impaired complex I activity, and antioxidant protection of cell membranes. It serves as a mechanistic tool for probing how short-chain quinones influence energy metabolism and neuronal survival in model systems.

Research Benefits

Idebenone and Mitochondrial Energy Metabolism

Research indicates that idebenone can shuttle electrons directly to complex III of the mitochondrial respiratory chain, bypassing impaired complex I activity to help sustain cellular ATP production. Studies have investigated this mechanism across a panel of short-chain quinones, finding that idebenone’s physicochemical properties support both this electron-shuttling capacity and reduced lipid peroxidation in cell culture models.

Idebenone and Visual Function

Studies propose that idebenone’s antioxidant activity supports retinal ganglion cell function in models of mitochondrial DNA-related visual impairment. Researchers use this model to explore how idebenone administration relates to visual acuity outcomes, with a randomized placebo-controlled trial finding that research participants with discordant baseline visual acuity between eyes showed the most measurable benefit across secondary visual endpoints compared to placebo.

Idebenone and Astrocyte Neuroprotection

Research suggests idebenone increases nerve growth factor production in cultured astrocytes, which contributes to an anti-apoptotic effect against hydrogen peroxide-induced reperfusion injury. Studies have investigated this pathway using kinase inhibitors, finding that the protective effect depends on downstream ERK and phosphatidylinositol-3 kinase signaling triggered by nerve growth factor.

Summary

Idebenone Powder is a synthetic CoQ10 analog supplied exclusively for laboratory research. It supports investigation into three distinct areas: mitochondrial energy metabolism, visual function in models of mitochondrial DNA-related impairment, and astrocyte neuroprotection. As with all research compounds in this catalog, idebenone is intended strictly for research use and not for human or veterinary application.

Disclaimer

This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.

Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).

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IMPORTANT NOTICE: All products showcased on our platform are EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH APPLICATIONS. They are expressly not intended for veterinary or human utilization.

References

1. Erb M, Hoffmann-Enger B, Deppe H, et al. Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I. PLoS One. 2012 Apr 27;7(4):e36153. doi: 10.1371/journal.pone.0036153. PMID: 22558363. Read More
2. Klopstock T, Yu-Wai-Man P, Dimitriadis K, et al. A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy. Brain. 2011 Jul 25;134(Pt 9):2677-86. doi: 10.1093/brain/awr170. PMID: 21788663. Read More
3. Takuma K, Yoshida T, Lee E, Mori K, Kishi T, Baba A, Matsuda T. CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. Eur J Pharmacol. 2000 Oct 20;406(3):333-9. doi: 10.1016/s0014-2999(00)00701-9. PMID: 11040339. (CV-2619 is the original Takeda manufacturer’s code name for idebenone.) Read More