Urolithin B Powder

Description

Urolithin B Powder
CAS Number	1139-83-9
Molar Mass	212.20 g/mol
Chemical Formula	C13H8O3
IUPAC Name	3-hydroxy-6H-benzo[c]chromen-6-one

Introduction

Urolithin B Powder is a gut microbiota-derived polyphenol metabolite, classified as a postbiotic, supplied strictly for laboratory and in vitro research use. It is studied by researchers investigating skeletal muscle protein balance, cardiomyocyte signaling, and enzyme inhibition mechanisms. Urolithin B is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.

Key Characteristics

Urolithin B Powder is manufactured to a high standard of chemical purity to support reproducible research outcomes. Each batch is formulated with attention to structural precision and lot-to-lot consistency, allowing researchers to rely on stable results across independent experiments.

Research Applications

Urolithin B is used in muscle physiology, cardiovascular, and enzymology research to investigate androgen receptor and mTORC1 signaling in skeletal muscle, Akt/mTOR-mediated cardiomyocyte survival pathways, and aromatase enzyme activity. It serves as a mechanistic tool for probing how gut-derived ellagitannin metabolites influence protein turnover, cell survival signaling, and steroidogenic enzyme function in model systems.

Research Benefits

Urolithin B and Skeletal Muscle Mass

Research indicates that Urolithin B enhances the growth and differentiation of cultured myotubes by increasing protein synthesis and repressing the ubiquitin-proteasome degradation pathway. Studies have investigated this mechanism using genetic and pharmacological approaches implicating the androgen receptor and a crosstalk with the mTORC1 pathway, finding that Urolithin B induced muscle hypertrophy in mice and reduced muscle atrophy following sciatic nerve denervation.

Urolithin B and Cardiomyocyte Survival

Studies propose that Urolithin B reduces cardiomyocyte apoptosis following hypoxic exposure by activating the Akt/mTOR signaling pathway. Researchers use this model to explore how this mechanism, along with suppression of NF-kB nuclear translocation and increased gap junction channel protein expression, relates to reduced susceptibility to arrhythmic changes after simulated myocardial injury in cell culture and animal models.

Urolithin B and Aromatase Enzyme Activity

Research suggests that among a panel of pomegranate ellagitannin-derived compounds, Urolithin B most effectively inhibits aromatase enzyme activity in a live-cell assay, with kinetic analysis indicating more than one inhibitory mechanism. Studies have investigated this activity alongside its effect on testosterone-induced proliferation in a hormone-responsive cell line, offering researchers a tool for studying steroidogenic enzyme regulation.

Summary

Urolithin B Powder is a gut microbiota-derived polyphenol metabolite supplied exclusively for laboratory research. It supports investigation into three distinct areas: skeletal muscle protein balance, cardiomyocyte survival signaling, and aromatase enzyme activity. As with all research compounds in this catalog, Urolithin B is intended strictly for research use and not for human or veterinary application.

Disclaimer

This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.

Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).

Our informational content is meticulously designed for research-oriented insights and is not a substitute for individual analysis and verification from credible sources before any purchasing decisions are made.

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IMPORTANT NOTICE: All products showcased on our platform are EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH APPLICATIONS. They are expressly not intended for veterinary or human utilization.

References

1. Rodriguez J, Pierre N, Naslain D, Bontemps F, Ferreira D, Priem F, Deldicque L, Francaux M. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Mar 1;8(4):583-597. doi: 10.1002/jcsm.12190. PMID: 28251839. Read More
2. Huang X, Gao H, Jiang X, Zheng Z. Urolithin B, a Gut Microbiota Metabolite, Reduced Susceptibility to Myocardial Arrhythmic Predisposition after Hypoxia. Dis Markers. 2022 Feb 8;2022:6517266. doi: 10.1155/2022/6517266. PMID: 35178131. Read More
3. Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila). 2010 Jan;3(1):108-13. doi: 10.1158/1940-6207.CAPR-08-0225. PMID: 20051378. Read More