Description
| CMS-121 Powder | |
| CAS Number | 1353224-53-9 |
| Molar Mass | 321.38 g/mol |
| Chemical Formula | C20H19NO3 |
| IUPAC Name | 4-[4-(cyclopentyloxy)quinolin-2-yl]benzene-1,2-diol |
Introduction
CMS-121 Powder is a synthetic flavonoid derivative belonging to the quinolone class, developed through chemical modification of the natural flavonoid fisetin. It is supplied strictly for laboratory and in vitro research use and is studied by researchers investigating acetyl-CoA metabolism, mitochondrial homeostasis, and oxidative stress pathways in models of biological aging. CMS-121 is not intended for human consumption, veterinary use, or any application outside of a controlled research setting.
Key Characteristics
CMS-121 Powder is manufactured to a high standard of chemical purity to support reproducible research outcomes. Each batch is formulated with attention to structural precision and lot-to-lot consistency, allowing researchers to rely on stable results across independent experiments.
Research Applications
CMS-121 is used in neurobiology and metabolic aging research to investigate fatty acid synthase inhibition, acetyl-CoA carboxylase 1 (ACC1) inhibition, and organ-specific protein changes associated with aging. It serves as a mechanistic tool derived from structure-activity optimization of fisetin, offering researchers a way to probe how lipid and energy metabolism pathways relate to brain and kidney aging in model systems.
Research Benefits
CMS-121 and Lipid Peroxidation
Research indicates that CMS-121 targets fatty acid synthase, an enzyme involved in lipid metabolism, and that this interaction reduces excess lipid peroxidation and markers of inflammation in brain tissue. Studies have investigated this mechanism in a transgenic aging mouse model, finding that CMS-121 administration was associated with alleviated cognitive decline alongside modulation of lipid metabolism, supporting a role for fatty acid synthase inhibition as a target relevant to lipid peroxidation-related toxicity research.
CMS-121 and Acetyl-CoA Metabolism
Studies propose that CMS-121 inhibits acetyl-CoA carboxylase 1, raising cellular acetyl-CoA levels and preserving mitochondrial homeostasis in cell culture and in rapidly aging mice. Researchers use this model to explore how this metabolic mechanism relates to increased histone H3K9 acetylation, a site linked to memory-related gene expression, alongside reductions in cognitive decline markers in an aging mouse model.
CMS-121 and Kidney Protein Homeostasis
Research suggests that CMS-121 administration restores more youthful protein levels in both brain and kidney tissue of rapidly aging mice, with tissue-specific patterns of protein alteration in each organ. Studies have investigated this effect in a senescence-accelerated mouse model during the final quadrant of the animals’ lifespan, when age-associated kidney changes typically begin to emerge.
Summary
CMS-121 Powder is a synthetic fisetin-derived quinolone compound supplied exclusively for laboratory research. It supports investigation into three distinct areas: lipid peroxidation and fatty acid synthase inhibition, acetyl-CoA metabolic regulation, and kidney protein homeostasis in aging models. As with all research compounds in this catalog, CMS-121 is intended strictly for research use and not for human or veterinary application.
Disclaimer
This content is presented exclusively for educational purposes and should not be construed as medical advice. THE MATERIALS REFERENCED HEREIN ARE EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH USE.
Any clinical research initiatives must be conducted under the guidance of the relevant Institutional Review Board (IRB). Similarly, preclinical research involving animals must comply with the directives of the Institutional Animal Care and Use Committee (IACUC), adhering to the standards delineated by the Animal Welfare Act (AWA).
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IMPORTANT NOTICE: All products showcased on our platform are EXCLUSIVELY INTENDED FOR LABORATORY AND RESEARCH APPLICATIONS. They are expressly not intended for veterinary or human utilization.
References
- Ates G, Goldberg J, Currais A, Maher P. CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer’s disease. Redox Biol. 2020 Jul 21;36:101648. doi: 10.1016/j.redox.2020.101648. PMID: 32863221. Read More
- Currais A, Huang L, Goldberg J, Petrascheck M, Ates G, Pinto-Duarte A, Shokhirev MN, Schubert D, Maher P. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8:e47866. doi: 10.7554/eLife.47866. PMID: 31742554. Read More
- Kepchia D, Currais A, Dargusch R, Finley K, Schubert D, Maher P. Geroprotective effects of Alzheimer’s disease drug candidates. Aging (Albany NY). 2021 Feb 6;13(3):3269-3289. doi: 10.18632/aging.202631. PMID: 33550278. Read More
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