MOTS-c

Description

Properties

CAS Number	1627580-64-6
Molar Mass	2174.7 g/mol
Chemical Formula	C101H152N28O22S2
Synonyms	UNII-A5CV6JFB78, A5CV6JFB78, orb2279120, SCHEMBL29545955 Mitochondria-derived peptide mots-c
Shelf Life	30 days when stored properly at 4°C.

Product Overview of MOTS-C Peptide

The MOTS-C peptide refers to the mitochondrial ORF of the 12S rRNA type-C. It is a 16-amino acid, mitochondria-derived peptide first reported in 2015. MOTS-C is encoded within mitochondrial DNA. It plays a regulatory role in metabolism, cellular stress response, and longevity pathways.

In experimental settings, the MOTS-C peptide was observed to activate AMP-activated protein kinase (AMPK). It also demonstrated the ability to modulate the folate-AICAR pathway. Through these actions, MOTS-C purportedly enhances glucose uptake, promotes fatty acid oxidation, and improves metabolic flexibility.

Despite these potential effects, MOTS-C is still classified as a research chemical. It is not approved for human consumption and should only be purchased for research purposes.

Why Choose BC9 to Buy MOTS-C Peptide Online

When considering where to buy MOTS-C, quality service and trust are non-negotiable. At BC9, we go beyond simply offering MOTS-C peptide for sale. We also provide a complete research experience built on reliability and transparency.

Here are compelling reasons why BC9 is your trusted online supplier of research peptides:

• 100% Customer Satisfaction: Our priority is ensuring every order meets your expectations, from packing to delivery.
• Comprehensive Catalogue: In addition to MOTS-C, BC9 offers a wide range of research peptides and compounds. This makes us support diverse scientific research.
• Transparent Documentation: Every vial comes with a certificate of analysis (COA). This means you can buy MOTS-C peptide with full confidence in its purity and consistency.
• Research-Grade Ingredients: Manufactured under strict quality controls, our peptide products are suitable for advanced research efforts.
• 24/7 Customer Support: Our team is always available to meet your needs. We can provide guidance on how to order MOTS-C peptide online. We are also here to address any post-purchase questions.
• Multiple Payment Options: Experience flexible and secure payment methods when you decide to purchase MOTS-C from BC9.
• Free U.S. Shipping: This applies to orders above $150. We aim to help you maximize value while receiving reliable and discreet delivery.

MOTS-C Peptide: Potential Research Applications

MOTS-C and Metabolic Regulation

MOTS-C has been shown to regulate metabolic homeostasis directly. This is attributed to the peptide’s activation of AMP-activated protein kinase (AMPK). The latter is a known master regulator of energy and balance. [1]

Because MOTS-C may stimulate glucose uptake and fatty acid oxidation, this compound can help cells adapt to nutrient stress. [2]

MOTS-C in Aging and Longevity Research

In research studies, it was observed that MOTS-C declines with age. As such, many consider this compound a mitochondrial-derived “aging signal.” [3]

In older mice, MOTS-C administration was purportedly able to restore metabolic flexibility, improve physical performance, and extend markers of healthspan. [4] These findings suggest MOTS-C may be part of a broader class of mitochondrial-encoded peptides. This means that the chemical may protect against age-related decline.

MOTS-C and Exercise Physiology

Exercise induces the expression and secretion of MOTS-C. This indicates that the investigational compound may act as an “exercise mimetic” peptide. [4]

Now, some studies confirm that MOTS-C levels rise following physical activity. They even indicate that this may enhance skeletal muscle adaptation and improve resilience to metabolic stress. [5]

In addition, MOTS-C may help mediate exercise benefits in older research models. If this is the case, this research chemical may help provide a mechanistic link between physical activity and mitochondrial health.

MOTS-C and Inflammation / Oxidative Stress

Mitochondrial peptides, such as MOTS-C, have been identified as potential immunomodulators. This observation is based on some laboratory-based studies. [6] [7] [8]

In cellular and animal models, MOTS-C was able to reduce markers of oxidative damage. Theoretically, the compound may protect against metabolic stress and tissue inflammation. [9]

MOTS-C in Bone and Skeletal Research

Some studies have linked MOTS-C to skeletal health.

In vitro, the research chemical promoted osteoblast differentiation and proliferation. This action occurs while MOTS-C inhibits osteoclast formation. Thus, it may tip the balance toward bone formation. [11]

In vivo models suggest that MOTS-C may counteract osteoporosis by supporting bone mineralization and reducing bone resorption. [12]

MOTS-C and Cognitive / Neurological Research

According to emerging scientific evidence, MOTS-C may cross the blood-brain barrier. This can be achieved if MOTS-C is paired with a cell-penetrating peptide. Nevertheless, MOTS-C may exert influence on neuronal metabolism and resilience. [13]

Animal models given MOTS-C have demonstrated protective effects against high-fat diet-induced cognitive decline. [14] This can possibly be explained by the following:

• MOTS-C’s ability to enhance mitochondrial efficiency
• MOTS-C’s property of reducing neuroinflammation

IMPORTANT: All of the potential effects mentioned in this section are derived from laboratory trials and experiments. These have not been proven to be effective on humans. These are provided for information purposes only. MOTS-C is not approved for human consumption and should not be used for therapeutic purposes. BC9 sells its MOTS-C vial for research studies alone.

Frequently Asked Questions

What should I consider before I buy MOTS-C peptide for sale?

When planning to purchase the MOTS-C peptide, it’s important to evaluate product purity, documentation, and supplier reliability. At BC9, every vial comes with a certificate of analysis (COA), leading to product quality. 

Does MOTS-C lead to side effects in research models?

Current studies indicate that MOTS-C is generally well-tolerated within laboratory research settings. However, possible adverse reactions may include fatigue and sleep disturbances.

Can I order MOTS-C peptide online?

Yes. BC9 makes it easy to order MOTS-C online with secure checkout, multiple payment options, and fast and discreet shipping. 

What is MOTS-C being studied for?

MOTS-C is currently being researched for its potential role in metabolism, aging, and exercise physiology. These are aligned to the compound’s mechanisms of action, which involve activating AMPK and supporting insulin sensitivity.

How is MOTS-C different from other research peptides?

Unlike many peptides that are encoded in nuclear DNA, MOTS-C is mitochondria-derived. This property makes the compound unique from its class. It also enables MOTS-C to link mitochondrial function to systemic metabolism and stress adaptation.

While other peptides often target single pathways, MOTS-C acts as a metabolic regulator with broad influence. In research settings, the compound was observed to affect glucose, lipid, and cellular stress responses.

Is the MOTS-C peptide legal?

MOTS-C is not approved by the FDA for human consumption. Thus, it cannot be marketed as a supplement or therapeutic drug. This compound can only be purchased for scientific research purposes.

References:

1. Lee, C., Zeng, J., Drew, Brian G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S.-J., Mehta, H., Hevener, Andrea L., de Cabo, R., & Cohen, P. (2015). The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabolism, 21(3), 443–454. https://doi.org/10.1016/j.cmet.2015.02.009 
2. Gao, Y., Wei, X., Wei, P., Lu, H., Zhong, L., Tan, J., Liu, H., & Liu, Z. (2023). MOTS-c Functionally Prevents Metabolic Disorders. Metabolites, 13(1), 125–125. https://doi.org/10.3390/metabo13010125 
3. Mohtashami, Z., Singh, M. K., Salimiaghdam, N., Ozgul, M., & Kenney, M. C. (2022). MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. International Journal of Molecular Sciences, 23(19), 11991. https://doi.org/10.3390/ijms231911991 
4. Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., Merry, T. L., & Lee, C. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12(1), 470. https://doi.org/10.1038/s41467-020-20790-0 
5. Feng, Y., Rao, Z., Tian, X., Hu, Y., Yue, L., Meng, Y., Zhong, Q., Chen, W., Xu, W., Li, H., Hu, Y., & Shi, R. (2024). Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion. Free Radical Biology and Medicine, 227, 619–628. https://doi.org/10.1016/j.freeradbiomed.2024.12.038 
6. Li, Y., Li, Z., Ren, Y., Lei, Y., Yang, S., Shi, Y., Peng, H., Yang, W., Guo, T., Yu, Y., & Xiong, Y. (2023). Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities. Journal of Advanced Research, 64, 99–115. https://doi.org/10.1016/j.jare.2023.11.018 
7. Zheng, Y., Wei, Z., & Wang, T. (2023). MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1120533 
8. Gao, Y., Wei, X., Wei, P., Lu, H., Zhong, L., Tan, J., Liu, H., & Liu, Z. (2023). MOTS-c Functionally Prevents Metabolic Disorders. Metabolites, 13(1), 125–125. https://doi.org/10.3390/metabo13010125 
9. Zhong, P., Peng, J., Hu, Y., Zhang, J., & Shen, C. (2022). Mitochondrial-derived peptide MOTS‐c prevents the development of heart failure under pressure overload conditions in mice. Journal of Cellular and Molecular Medicine, 26(21), 5369–5378. https://doi.org/10.1111/jcmm.17551 
10. Tang, M., Su, Q., Duan, Y., Fu, Y., Liang, M., Pan, Y., Yuan, J., Wang, M., Pang, X., Ma, J., Laher, I., & Li, S. (2023). The role of MOTS-c-mediated antioxidant defense in aerobic exercise in alleviating diabetic myocardial injury. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-47073-0 
11. Che, N., Qiu, W., Wang, J-K., Sun, X-X., Xu, L-X., Liu, R., & Gu, L. (2019). MOTS-c improves osteoporosis by promoting the synthesis of type I collagen in osteoblasts via TGF-β/SMAD signaling pathway. European Review for Medical and Pharmacological Sciences, 23(8), 3183–3189. https://doi.org/10.26355/eurrev_201904_17676 
12. Yi, X., Hu, G., Yang, Y., Li, J., Jin, J., & Chang, B. (2023). Role of MOTS-c in the regulation of bone metabolism. Frontiers in Physiology, 14. https://doi.org/10.3389/fphys.2023.1149120 
13. Jiang, J., Chang, X., Nie, Y., Shen, Y., Liang, X., Peng, Y., & Chang, M. (2021). Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ1–42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation. ACS Chemical Neuroscience, 12(9), 1506–1518. https://doi.org/10.1021/acschemneuro.0c00782 
14. Zhai, D., Ye, Z., Jiang, Y., Xu, C., Ruan, B., Yang, Y., Lei, X., Xiang, A., Lu, H., Zhu, Z., Yan, Z., Wei, D., Li, Q., Wang, L., & Lu, Z. (2017). MOTS-c peptide increases survival and decreases bacterial load in mice infected with MRSA. Molecular Immunology, 92, 151–160. https://doi.org/10.1016/j.molimm.2017.10.017