PT 141

Description

Properties

Product Overview of PT 141 Peptide

PT 141 is also called bremelanotide. When studied in the lab, PT 141 is recognized as a synthetic cyclic heptapeptide. It acts as an agonist of certain melanocortin receptors (notably MC3R and MC4R), which are situated in the brain.

How PT 141 Works

PT 141 was observed to mimic part of the structure of the alpha-melanocyte-stimulating hormone (α-MSH). As such, this research peptide may bind to melanocortin receptors in the brain of research subjects. The MC3R and MC4R receptors are involved in certain neural circuits that regulate sexual behavior, arousal, and other motivational states. [1]

In preclinical models (e.g., rats), administration of PT 141 increases neuronal activity in hypothalamic regions when measured by markers such as c-Fos. [2]

Among male animals, PT 141 may induce penile erections. This effect was observed even in the absence of sexual cues. [3] On the other hand, in female rodents, PT 141 could potentially enhance sexual behavior. The latter includes increased solicitation and desire-related disposition. [4]

IMPORTANT: PT 141 is not recommended for casual use or self-administration. All studies mentioned occurred under controlled experimental conditions. PT 141 is not FDA-approved for human consumption. Use this research compound for laboratory studies only.

Why Choose BC9 to Buy PT 141 Peptide Online

Researchers who buy PT 141 for sale, even those who ask “Where to buy PT 141,” are typically looking to source from a reliable provider. BC9 is currently positioned as one of the most reliable online sources for research peptides. 

When you buy PT 141 peptide online from us, you can expect to receive a free mixing kit (free bacteriostatic water + syringes). This is our way of helping you keep your research moving forward.

Moreover, here are compelling reasons why BC9 is your go-to source as you buy PT 141 peptide for sale:

• Scientific Innovation: BC9 supports innovative research studies. This enables us to provide our customers with a wide catalogue of research compounds that could influence various biological pathways.
• Precision Formulation: Every product that we release is formulated explicitly for research. The PT 141 we sell is formulated with meticulous precision to achieve accurate measurement, stability, and predictable behavior. Each is vital under experimental conditions.
• Consistency Across Batches: At BC9, consistency is paramount. This leads us to ensure that each batch undergoes strict quality control. Through this practice, our researcher customers can expect reproducibility from one batch to another.
• Trusted Third-Party Testing: To verify purity, identity, and overall quality, every research compound is independently tested by accredited third-party laboratories. With this standard, BC9 ensures that what you receive matches specifications.
• Respectful and Responsive Customer Support: We care about your research moving forward, which is why our knowledgeable and responsive customer support team is here for you. We are prepared 24/7 to answer any concerns regarding product quality and processing.

PT 141 Peptide: Potential Research Applications

Modulating Sexual Behavior in Animal Models

Female rodents who received PT 141 administration showed a dose-dependent response. This includes an increase in sexually desirable-related solicited behaviors. Examples are hops, darts, and proceptive approaches. [5]

On the flip side, male mouse models have demonstrated erectile responses. These occur following systemic administration of PT 141. The finding could be because PT 141 may exert influence on a central neural mechanism. [1]

Potential Effect on Hypoactive Sexual Desire

PT 141’s potential application also includes its possible effect on hypoactive sexual desire disorder (HSDD). This is typically characterized by persistently low sexual desire that causes distress.

In a double-blind crossover trial, intranasal PT 141 increased moderate-to-high sexual desire ratings compared to placebo. The study added that this effect persists up to 24 hours. [6]

Erectile Dysfunction Studies

Research has also explored PT 141’s effects on erectile dysfunction (ED) among specific research models.

• In some studies, subcutaneous PT 141 doses produced significant increases in penile rigidity compared to placebo. This result was measured using RigiScan monitoring. [7]
• Intranasal administration of the peptide demonstrated a dose-dependent effect. Interestingly, the onset of action among research models is within ~30 minutes. Moreover, the mechanism is centrally mediated through melanocortin receptor agonism. [8]

Combination Studies and Central Mechanisms

PT 141 has also been tested in combination with PDE5 inhibitors.

Some research subjects with ED were partial responders to PDE5 inhibitors. When these received a combined administration of PT 141 and PDE5 inhibitors, there was a significant enhancement of erectile responses. [9]

IMPORTANT: All findings above are derived from controlled experimental and clinical research environments. PT 141 remains classified as an experimental compound. Thus, it is not approved for human consumption. BC9 sells its PT 141 vial strictly for laboratory research purposes.

Frequently Asked Questions

What should I look for when I buy PT 141 online?

Look for research-grade purity, third-party testing, certificates of analysis, and consistent batch quality. These features are necessary for a successful PT 141 experiment.

Does PT 141 come with possible side effects?

Yes. Some studies report nausea and flushing as possible side effects of PT 141.

How can PT 141 potentially enhance sexual drive among research subjects?

PT 141 was observed to act on central melanocortin receptors. These are specifically MC3R and MC4R. The receptors are linked to arousal and sexual motivation pathways.

What makes BC9 the best place to buy PT 141 for sale?

BC9 provides premium quality research compounds. Each of our products is subjected to third-party testing, with an accompanying updated certificate of analysis.

Can PT 141 be paired with other research compounds?

Yes, some studies have explored pairing PT 141 with PDE5 inhibitors. The blend has shown potential synergistic effects under research investigations.

References:

1. Molinoff, P. B., Shadiack, A. M., Earle, D., Diamond, L. E., & Quon, C. Y. (2003). PT‐141: a melanocortin agonist for the treatment of sexual dysfunction. Annals of the New York Academy of Sciences, 994(1), 96–102. https://doi.org/10.1111/j.1749-6632.2003.tb03167.x
2. Wessells, H., Blevins, J., & Vanderah, T. (2005). Melanocortinergic control of penile erection. Peptides, 26(10), 1972–1977. https://doi.org/10.1016/j.peptides.2004.11.035
3. King, S. H., Mayorov, A. V., Balse-Srinivasan, P., Hruby, V. J., Vanderah, T. W., & Wessells, H. (2007). Melanocortin receptors, melanotropic peptides, and penile erection. https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/
4. Palatin Technologies’ PT-141 increases sexual behavior in female animals. (2001, October 26). EurekAlert! https://www.eurekalert.org/news-releases/837832
5. Pfaus, J. G., Shadiack, A., Van Soest, T., Tse, M., & Molinoff, P. (2004). Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proceedings of the National Academy of Sciences, 101(27), 10201–10204. https://doi.org/10.1073/pnas.0400491101
6. Diamond, L. E., Earle, D. C., Heiman, J. R., Rosen, R. C., Perelman, M. A., & Harning, R. (2006). An Effect on the Subjective Sexual Response in Premenopausal Women with Sexual Arousal Disorder by Bremelanotide (PT-141), a Melanocortin Receptor Agonist. The Journal of Sexual Medicine, 3(4), 628–638. https://doi.org/10.1111/j.1743-6109.2006.00268.x
7. Rosen, R. C., Diamond, L. E., Earle, D. C., Shadiack, A. M., & Molinoff, P. B. (2004). Evaluation of the safety, pharmacokinetics, and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra®. International Journal of Impotence Research, 16(2), 135–142. https://doi.org/10.1038/sj.ijir.3901200
8. Diamond, L. E., Earle, D. C., Rosen, R. C., Willett, M. S., & Molinoff, P. B. (2004). Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties, and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction. International Journal of Impotence Research, 16(1), 51–59. https://doi.org/10.1038/sj.ijir.3901139 
9. Diamond, L., Earle, D., Garcia, W., & Spana, C. (2005). Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology, 65(4), 755–759. https://doi.org/10.1016/j.urology.2004.10.060