Description
Introduction
Bronchogen, a synthetic research peptide, is currently being studied for its potential role in supporting pulmonary tissue function and immune regulation. Preclinical models suggest that Bronchogen may help modulate inflammatory responses in the respiratory tract, offering insight into pathways that influence airway health and immune resilience.
| Bronchogen | |
| CAS Number | Not Assigned (N/A) |
| Molar Mass | ~446.45 g/mol |
| Chemical Structure | C₁₈H₃₀N₄O₉ |
| IUPAC Name | Ala‑Glu‑Asp‑Leu (AEDL) |
Key Characteristics
Bronchogen is structurally designed to mimic certain endogenous peptides associated with tissue repair and immune signaling in the lungs. It is believed to interact with receptors that regulate mucosal defense, epithelial repair, and cellular immune responses. Researchers are exploring how Bronchogen may influence cytokine activity and oxidative stress in the lungs, key factors in respiratory integrity and immune balance.
Research Applications
Bronchogen is being investigated across a variety of research domains. Key areas of interest include:
Bronchial Tissue Repair & Integrity
In rodent models exposed to airway irritants, Bronchogen appeared to restore bronchial epithelial structure, reducing goblet cell hyperplasia and squamous metaplasia, while promoting ciliated cell restoration and surfactant protein production (e.g., SP‑B).
Cellular Aging & Differentiation
Bronchogen may upregulate transcription factors such as Hoxa3, showing 1.4–1.7× increases in aged cell models, suggesting a geroprotective function in aging bronchial tissue.
Genomic & Epigenetic Stabilization
Bronchogen may act as a DNA-stabilizing ligand, increasing the DNA melting temperature by ~3 °C, indicating enhanced thermostability and potential protection against DNA damage.
Summary
Bronchogen is a lung-focused bioregulator peptide showing promising results in research environments. Its mechanism of action appears to center around enhancing DNA stability and modulating gene expression through epigenetic pathways. Studies suggest it supports bronchial epithelial repair, reduces inflammation, and contributes to the normalization of tissue structure. Additionally, Bronchogen has demonstrated potential geroprotective activity by promoting transcription factors linked to cellular differentiation. These characteristics make it a valuable candidate for ongoing respiratory research, particularly in areas related to epithelial restoration, airway inflammation, and age-associated decline in pulmonary function.
Disclaimer
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References
Monaselidze JR, Khavinson VKh, Gorgoshidze MZ, Khachidze DG, Lomidze EM, Jokhadze TA, Lezhava TA.
Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability.
Bull Exp Biol Med. 2011 Jan;150(3):375–377. doi:10.1007/s10517-011-1146-x. PMID: [Read More]
Zakutskiĭ AN, Chalisova NI, Ryzhak GA, Aniskina AI, Filippov SV, Zeziulin PN.
The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats.
Adv Gerontol. 2006;19:93–96. Russian. PMID: [Read More]
Khavinson VKh, Linkova NS, Polyakova VO, Kheifets OV, Tarnovskaya SI, Kvetnoy IM.
Peptides tissue-specifically stimulate cell differentiation during their aging.
Bull Exp Biol Med. 2012 May;153(1):148–151. doi:10.1007/s10517-012-1664-1. PMID: [Read More]
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